CD300a-PE

A22328

List Price - 565.50


The CD300a, also known as inhibitory receptor protein (IRp60), is a surface molecule of 60kDa expressed by all human natural killer (NK) cells. The IRp60 gene, located on human chromosome region 17q25 encodes a molecule, highly O- and N-glycosylated, belonging to the immunoglobulin superfamily (Ig-SF) that displays one extracellular Ig-like domain of the V-type, a hydrophobic transmembrane portion and a cytoplasmic tail containing ITIM motifs involved in the inhibitory function. The ligand of the CD300a is still unknown but CD300a does not appear to recognize HLA-class I molecules. Upon cross-linking, IRp60 recruits and activates SH2-containing phosphatases SHP-1 and SHP-2 which switch off the activating signaling cascade by dephosphorylating a variety of tyrosine phosphorylated proteins. Cross-linking of IRp60 by E59.126 monoclonal antibody strongly inhibits the spontaneous cytotoxicity of NK cells as well as the NK-mediated cytolytic activity induced via different non-HLA-specific or HLA-specific activating receptors. CD300a may play a more general role in the regulation of the immune response since it is expressed on other cell types, including T lymphocyte subsets, monocytes and granulocytes.

Caractéristiques

Target Species Human
Specificity CD300a
Other Names CD300a, CMRF35H, IRp60
Fluorochrome PE
Regulatory Status ASR
Size 1 mL
Format Liquid
Flow Product Line IOTest
Clone E59.126
Isotype IgG1 Mouse
Clone Description The E59.126 antibody has been used in flow cytometry and Western Blotting to characterize IRp60.

Technical Documents

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