Optima AUC Features

Analytical ultracentrifugation for macromolecule characterization in solution

Beckman Coulter introduced the first AUC sample characterization instrument to help the scientific community power new discoveries. That tradition continues into the 21st century with the new Optima AUC system.

This latest tool is the most robust technology for providing data used to determine protein molecular weight in basic protein research and quantification of aggregation levels for academic and biopharma research.

“The results of AUC are explicit, reliable, and reproducible. AUC is my method of choice to characterize macromolecules and precisely study protein-protein interactions.”

Jia Ma, Ph.D. Director
Bioanalytical Core, Purdue University


The Optima AUC combines the power of a centrifuge to provide particle sedimentation with the functionality of optical modules to detect the sedimentation over time. It provides the data you need even faster, so you can make new discoveries in less time.

Summary of features and benefits:

Enables sample recovery
Avoids dilution effects
Analyzes samples in a matrix-free environment
Has minimal buffer constraints
Enables detection at low concentrations
Requires low sample volume (0.1 mL minimum)
Delivers high-throughput analysis – up to 7 samples in a single run
Requires no standards – relies upon first principles of thermodynamics

Analyzes a wide array of particles in native, matrix-free conditions, including:
Extracellular vesicles
Drug conjugates
Viral payload
Provides data which can answer more critical questions than any other comparable technique, including:

Enables precise analysis of complex systems at discrete wavelengths (up to 20) in minimal time.

Time Savings

• Generates faster results as acquisition time is no longer additive.
• Provides even more scans with the use of an An-50 Ti 8-hole rotor.

Ease of Use

Optima AUC Ease of Use

Modular design provides absorbance and interference optical systems—with the option to install up to 3 independent, simultaneous detection systems (see photo).
User-friendly touchscreen display indicates intuitive progression of experimental design.
Remote monitoring capabilities let you set up, monitor and extract data from virtually any location.
Compatibility with ProteomeLab XL cells and rotors—and widely used analytical software (e.g., UltraScan, SEDFIT/SEDPHAT, SEDANAL, DCDT+)—helps simplify the upgrade process.
Data Quality

Delivers cleaner data by providing higher radial resolution and higher signal-to-noise ratio.
Delivers higher precision, reproducibility and accuracy than the ProteomeLab XL.
Optima AUC Live Data Acquisition