CD7-APC-A700

A70201

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The CD7 antigen is a membrane-embedded glycoprotein with a molecular weight of 40 kDa. It is expressed at an early stage of T lineage ontogeny, during the extrathymic prothymocytic formation. CD7 expression persists throughout T lymphocytes differentiation defining CD7 as a pan-T marker. It is also expressed on thymocytes, on the majority of resting T lymphocytes, and Natural Killer cells (NK), and on a subset of pre-B lymphocytes and B lymphocytes from foetal bone marrow. CD7 expression is also detected on pluripotent hematopoietic stem cells. Mature B-lymphocytes, cells from erythroid, myeloid and megacaryocytic lineage do not express the CD7 molecule. The CD7 molecule is involved in T lymphocytes activation. Its expression may be quantitatively up-regulated on stimulated T lymphocytes. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.

Caractéristiques

Target Species Human
Specificity CD7
Other Names CD7, gp40, T cell leukemia antigen
Fluorochrome APC-Alexa Fluor* 700
Regulatory Status ASR
Size 0.5 mL
Format Liquid
Flow Product Line IOTest
Clone 8H8.1
Isotype IgG2a Mouse

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