CD197-PC7

B46025

List Price - 410.70


CCR7 is G protein-coupled receptors (GPCR) with seven transmembrane receptors. It binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity through their effects on interactions between T cells and dendritic cells. The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs, and the migration of dendritic cells into afferent lymphatic vessels. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B lymphocytes recirculate between B-cell-rich compartments (follicles or B zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. By bringing together T cells, B cells, and DCs to form functional microenvironments in secondary lymphoid organs, CCR7 has been identified as a major homing receptor and important regulator for initiating an antigen-specific immune response.

Caractéristiques

Target Species Human
Specificity CD197
Other Names CCR7, CD197
Fluorochrome PC7
Regulatory Status ASR
Size 0.5 mL
Format Liquid
Flow Product Line IOTest
Clone G043H7
Isotype IgG2a Mouse

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