CD8-APC-A750

A94683

List Price - 400.10


The CD8 antigen is a disulfide-linked dimer, which exists either as a CD8α homodimer or as a CD8α/β heterodimer. CD8α is required for surface expression of CD8β. The molecular weight of each monomer of α or β is approximately 32-34 kDa. CD8 binds to a non-polymorphic domain (α3 domain) of MHC Class I molecules. CD8 is expressed on a subset of human peripheral blood T lymphocytes. A subset of NK cells possess the CD8 antigen but show low to medium density of expression. CD8α homodimer is expressed by NK cells and γ/δ+ T cells. CD8 is also present on most thymocytes where it is frequently co-expressed with CD4, and on a subpopulation of bone marrow cells. The CD8 molecule acts with the T Cell Receptor (TCR) as a coreceptor for MHC class I restricted antigen recognition. CD8 is widely used as a marker of cytotoxic T lymphocytes. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.

Caractéristiques

Target Species Human
Specificity CD8
Other Names CD8, T8 antigen
Fluorochrome APC-Alexa Fluor* 750
Regulatory Status CE
Size 50 Tests
Format Liquid
Flow Product Line IOTest
Clone B9.11
Isotype IgG1 Mouse
Clone Description The B9.11 monoclonal antibody recognizes the α chain of the CD8 molecule. It was used as a CD8 reference monoclonal antibody during HLDA 6 (ref. 6T-CD8.5).

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