Cyclin A2-PE Conjugated Antibody

B15092

List Price - 408.50


In humans, there are two A-type cyclins – an embryonic-specific cyclin A1 and a somatic cyclin A2. Cyclin A1 is only expressed in meiosis and very early embryos, whereas cyclin A2 is present in proliferating somatic cells. Cyclin A2 is a 48 kDa protein composed of 432 amino-acids. Cyclins control the activation of cyclin dependent kinases (CDKs) by associating with them to form a cyclin-CDK complex able to phosphorylate selected proteins and to induce downstream processes. The cyclin A2-CDK2 complex initiates DNA replication and is required for S phase progression. For passage through G2 to M phase, cyclin A2 complexes to the CDK1 (also called CDC2). Cyclin A2 is degraded via the ubiquitin-dependant proteolysis pathway in the early phases of mitosis.

Caractéristiques

Target Species Human
Specificity Cyclin A2
Fluorochrome PE
Regulatory Status ASR
Size 1 mL
Format Liquid
Flow Product Line IOTest
Clone 11B2G3
Isotype IgG1 Mouse

Customers Also Viewed

TOUS LES PRODUITS NE SONT PAS DISPONIBLES DANS TOUS LES PAYS
LA DISPONIBILITE DU PRODUIT ET LE STATUT REGLEMENTAIRE DEPENDENT DE L’ENREGISTREMENT SELON LE REGLEMENT APPLICABLE PAR PAYS