IgD-PE

B30653

List Price - 230.00


IgD, a member of the immunoglobulin (Ig) family, is expressed in naïve B cells. It exists in a transmembrane and a soluble form. IgD is, together with IgM, the first antibody isotypes expressed during B cell ontogeny. Bone marrow B cell precursors acquire surface IgM after assembling heavy (H) and light (L) chain variable region exons from prototypic variable (V), diversity (D) and joining (J) gene segments through an antigen-independent process. After leaving the bone marrow to colonize secondary lymphoid organs, B cells acquire surface IgD of the same specificity as surface IgM through alternative splicing of a pre-messenger RNA comprising V(D)J and both heavy chain constant μ (Cμ) and Cδ exons.

Caractéristiques

Target Species Human
Specificity IgD
Fluorochrome PE
Regulatory Status RUO
Size 50 Tests
Format Liquid
Flow Product Line IOTest
Clone IA6-2
Isotype IgG2a Mouse
Clone Description The IA6-2 monoclonal antibody binds specifically to the heavy chain of human IgD.

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