ZAP-70-PE

B57658

List Price - 410.30


Zap-70, a Syk family protein tyrosine kinase expressed in T and NK cells, plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement. Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues, presumably by two mechanisms: autophosphorylation and transphosphorylation by the Src family tyrosine kinase, Lck. Tyrosine phosphorylation of Zap-70 correlates with its increased kinase activity and downstream signaling events.

Caractéristiques

Target Species Human
Specificity ZAP-70
Fluorochrome PE
Regulatory Status RUO
Size 50 Tests
Format Liquid
Flow Product Line IOTest
Clone SBZAP
Isotype IgG1 Mouse
Clone Description The monoclonal antibody SBZAP was generated against a KLH-peptide sequence corresponding to the human ZAP-70 amino acid residues 280-309.

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