The P250 pre-sterile wide bore tips work with the Biomek NX, NXp, FX and FXp automation systems with the Multichannel or Span-8 pod and the Biomek 3000 P200L and MP200 Tools. The barrier tips reduce the chance of sample cross-contamination from aerosols. With a tip twice as large as standard tips, the P250s are used in an array of applications: library construction for next generation sequencing sample prep where the bead mixture is viscous; stem cell research to reduce the inadvertent cell lysis of large cell-aggregates of embryoid bodies; nucleic acid preparation to minimize DNA shearing; cellular applications where pipetting of viscous solutions such as glycerol solution is commonly used; bio-fuels/bio-energy research where cellulose slurries may clog standard tips; and crop research/seed development where samples may contain large particulates. Tips are manufactured to ensure straight, leak-proof products and guaranteed to be free of DNA, DNase/RNase, PCR inhibition, pyrogen/endotoxin and trace metals. Case of 10 racks.